MovDisordV3, Main, Exploration, bibRecord, 002A57

Relevance of COX-2 Gene Expression in Dementia with Lewy Bodies Associated with Alzheimer Pathology

Identifieur interne : 002A57 ( Main/Exploration ); précédent : 002A56; suivant : 002A58

Relevance of COX-2 Gene Expression in Dementia with Lewy Bodies Associated with Alzheimer Pathology

Auteurs : Marisa Saldana [Espagne] ; Laura Pujols [Espagne] ; Joaquim Mullol [Espagne] ; Jordi Roca-Ferrer [Espagne] ; Adriana Cardozo [Espagne] ; Esther Aguilar [Espagne] ; Mercè Bonastre [Espagne] ; Concepcio Marin [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0251865

Descripteurs français

Pascal (Inist)
- Démence à corps de Lewy, Démence d'Alzheimer, Parkinsonisme, Pathologie du système nerveux, Expression génique, Anatomopathologie, Cyclooxygenase 2, Tyrosine 3-monooxygenase.

English descriptors

KwdEn :
- Alzheimer disease, Anatomic pathology, Cyclooxygenase 2, Gene expression, Lewy body dementia, Nervous system diseases, Parkinsonism, Tyrosine 3-monooxygenase.

Abstract

The aim of the present study was to investigate whether cyclooxygenase-2 (COX-2) expression is involved in the pathogenesis of neurodegeneration in dementia with Lewy bodies (DLB) by measuring COX-2 mRNA and protein expression in frontal cortex and substantia nigra pars compacta of DLB and control human brains. DLB cases were classified as pure form or common form according to the absence or the presence of Alzheimer pathology including neurofibrillary tangles and amyloid deposits by Braak staging. Using Western Blot and Real-time Polymerase chain reaction (PCR) analysis, we have shown that cortical COX-2 protein levels were decreased in DLB cases (P < 0.01). However, no differences in nigral COX-2 mRNA expression were observed between control and DLB cases. In conclusion, the present results suggest that in DLB nigral COX-2 mRNA expression does not correlate with dopaminergic neurodegeneration and that the slight changes observed in the common type are probably due to the concomitant AD pathology.

Affiliations:

Espagne

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The aim of the present study was to investigate whether cyclooxygenase-2 (COX-2) expression is involved in the pathogenesis of neurodegeneration in dementia with Lewy bodies (DLB) by measuring COX-2 mRNA and protein expression in frontal cortex and substantia nigra pars compacta of DLB and control human brains. DLB cases were classified as pure form or common form according to the absence or the presence of Alzheimer pathology including neurofibrillary tangles and amyloid deposits by Braak staging. Using Western Blot and Real-time Polymerase chain reaction (PCR) analysis, we have shown that cortical COX-2 protein levels were decreased in DLB cases (P < 0.01). However, no differences in nigral COX-2 mRNA expression were observed between control and DLB cases. In conclusion, the present results suggest that in DLB nigral COX-2 mRNA expression does not correlate with dopaminergic neurodegeneration and that the slight changes observed in the common type are probably due to the concomitant AD pathology.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
</country>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Saldana, Marisa" sort="Saldana, Marisa" uniqKey="Saldana M" first="Marisa" last="Saldana">Marisa Saldana</name>
</noRegion>
<name sortKey="Aguilar, Esther" sort="Aguilar, Esther" uniqKey="Aguilar E" first="Esther" last="Aguilar">Esther Aguilar</name>
<name sortKey="Aguilar, Esther" sort="Aguilar, Esther" uniqKey="Aguilar E" first="Esther" last="Aguilar">Esther Aguilar</name>
<name sortKey="Bonastre, Merce" sort="Bonastre, Merce" uniqKey="Bonastre M" first="Mercè" last="Bonastre">Mercè Bonastre</name>
<name sortKey="Bonastre, Merce" sort="Bonastre, Merce" uniqKey="Bonastre M" first="Mercè" last="Bonastre">Mercè Bonastre</name>
<name sortKey="Cardozo, Adriana" sort="Cardozo, Adriana" uniqKey="Cardozo A" first="Adriana" last="Cardozo">Adriana Cardozo</name>
<name sortKey="Marin, Concepcio" sort="Marin, Concepcio" uniqKey="Marin C" first="Concepcio" last="Marin">Concepcio Marin</name>
<name sortKey="Marin, Concepcio" sort="Marin, Concepcio" uniqKey="Marin C" first="Concepcio" last="Marin">Concepcio Marin</name>
<name sortKey="Mullol, Joaquim" sort="Mullol, Joaquim" uniqKey="Mullol J" first="Joaquim" last="Mullol">Joaquim Mullol</name>
<name sortKey="Mullol, Joaquim" sort="Mullol, Joaquim" uniqKey="Mullol J" first="Joaquim" last="Mullol">Joaquim Mullol</name>
<name sortKey="Pujols, Laura" sort="Pujols, Laura" uniqKey="Pujols L" first="Laura" last="Pujols">Laura Pujols</name>
<name sortKey="Pujols, Laura" sort="Pujols, Laura" uniqKey="Pujols L" first="Laura" last="Pujols">Laura Pujols</name>
<name sortKey="Roca Ferrer, Jordi" sort="Roca Ferrer, Jordi" uniqKey="Roca Ferrer J" first="Jordi" last="Roca-Ferrer">Jordi Roca-Ferrer</name>
<name sortKey="Roca Ferrer, Jordi" sort="Roca Ferrer, Jordi" uniqKey="Roca Ferrer J" first="Jordi" last="Roca-Ferrer">Jordi Roca-Ferrer</name>
<name sortKey="Saldana, Marisa" sort="Saldana, Marisa" uniqKey="Saldana M" first="Marisa" last="Saldana">Marisa Saldana</name>
</country>
</tree>
</affiliations>
</record>

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Relevance of COX-2 Gene Expression in Dementia with Lewy Bodies Associated with Alzheimer Pathology

Relevance of COX-2 Gene Expression in Dementia with Lewy Bodies Associated with Alzheimer Pathology

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